GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs11799420 | 1 | rs11590714 | chr1:171716779 | VAMP4 | chr1:171669298-171711214:- | 0.24 | 6.62 | 5.81E-11 | Hippocampal atrophy |
| BRCA | cis | rs9437689 | 1 | rs11591183 | chr1:95561706 | CNN3 | chr1:95362509-95392735:- | 0.12 | 3.5 | 0.000485 | Phospholipid levels (plasma) |
| BRCA | cis | rs56322409 | 1 | rs11592213 | chr10:97396103 | ENTPD1 | chr10:97471536-97637022:+ | 0.17 | 5.86 | 6.16E-9 | Blood metabolite levels |
| BRCA | cis | rs983392 | 1 | rs11600716 | chr11:59924422 | MS4A4A | chr11:60048139-60076444:+ | -0.09 | -3.61 | 0.000317 | Alzheimer's disease (late onset) |
| BRCA | cis | rs11603691 | 1 | rs11602266 | chr11:57094509 | PRG2 | chr11:57151267-57191532:- | -0.21 | -3.66 | 0.000264 | Low high density lipoprotein cholesterol levels |
| BRCA | cis | rs11603691 | 1 | rs11603691 | chr11:57107617 | PRG2 | chr11:57151267-57191532:- | -0.2 | -3.44 | 0.000607 | Low high density lipoprotein cholesterol levels |
| BRCA | cis | rs1568889 | 1 | rs11603799 | chr11:28196488 | METT5D1 | chr11:28129798-28355054:+ | -0.12 | -3.44 | 0.000595 | Bipolar disorder |
| BRCA | cis | rs2555155 | 1 | rs11604149 | chr11:6519642 | TPP1 | chr11:6633997-6640692:- | 0.11 | 3.55 | 0.000399 | DNA methylation (variation) |
| BRCA | cis | rs7927771 | 1 | rs11605774 | chr11:47832793 | MADD | chr11:47290927-47351582:+ | 0.13 | 4.08 | 4.83E-5 | Subjective well-being |
| BRCA | cis | rs7927771 | 1 | rs11605774 | chr11:47832793 | MYBPC3 | chr11:47352958-47374253:- | -0.14 | -4.05 | 5.55E-5 | Subjective well-being |
| BRCA | cis | rs11603691 | 1 | rs11606862 | chr11:57012742 | PRG2 | chr11:57151267-57191532:- | 0.22 | 3.72 | 0.000213 | Low high density lipoprotein cholesterol levels |
| BRCA | cis | rs11603691 | 1 | rs11607950 | chr11:57107361 | PRG2 | chr11:57151267-57191532:- | -0.18 | -3.37 | 0.00077 | Low high density lipoprotein cholesterol levels |
| BRCA | cis | rs7953704 | 1 | rs11608788 | chr12:122608155 | LRRC43 | chr12:122652266-122688017:+ | -0.17 | -4.85 | 1.42E-6 | Urate levels |
| BRCA | cis | rs7953704 | 1 | rs11608792 | chr12:122608209 | LRRC43 | chr12:122652266-122688017:+ | -0.17 | -4.76 | 2.19E-6 | Urate levels |
| BRCA | cis | rs7953704 | 1 | rs11609875 | chr12:122608502 | LRRC43 | chr12:122652266-122688017:+ | -0.18 | -4.91 | 1.08E-6 | Urate levels |